Arsenal are scheduled to host Championship leaders Leeds United in the third round of the FA Cup on Monday night.
The Gunners recently picked up their first victory at home in 87 days after they beat Manchester United by a 2-0 scoreline in the Premier League.
That was also the first triumph under new head coach Mikel Arteta and the Spaniard will be aiming to build a winning run hereafter.
Emiliano Martinez has featured in every game outside of the Premier League this term and he is expected to replace Bernd Leno in goal against the Peacocks.
In the backline, there could be a complete reshuffle from the recent league game. Hector Bellerin and Bukayo Saka could slot into the full-back positions with Rob Holding and Shkodran Mustafi playing at the heart of the defence.
Likewise, in the midfield, Matteo Guendouzi and Joe Willock are likely to receive gametime, having featured from the bench under Arteta. The duo could be accompanied by Daniel Ceballos, who was in the matchday squad on New Year’s Day after more than a month off with a hamstring concern.
Further forward, Arteta has hinted that Alexandre Lacazette could be afforded with a rest and that could see Pierre-Emerick Aubameyang leading the line once more. Nicolas Pepe is likely to start the game on the right-wing after featuring for only 60 minutes against United.
The Ivorian could be accompanied by Gabriel Martinelli on the opposite flank, provided he has been able to overcome a hamstring issue, which has kept him out of action since the Bournemouth game on Boxing Day.